{"id":2868,"date":"2023-06-14T11:47:53","date_gmt":"2023-06-14T10:47:53","guid":{"rendered":"https:\/\/archive.belbi.bg.ac.rs\/2023\/?post_type=abstract&p=2868"},"modified":"2023-06-14T18:49:37","modified_gmt":"2023-06-14T17:49:37","slug":"numerical-and-biological-modeling-approach-in-the-analysis-of-the-cancer-viability-and-apoptosis","status":"publish","type":"abstract","link":"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/numerical-and-biological-modeling-approach-in-the-analysis-of-the-cancer-viability-and-apoptosis\/","title":{"rendered":"Numerical and Biological Modeling Approach in the Analysis of the Cancer Viability and Apoptosis"},"content":{"rendered":"\n

Katarina Virijevi\u01071,5*<\/sup>, Marko \u017divanovi\u01071<\/sup>, Marina Gazdi\u0107 Jankovi\u01072<\/sup>, Amra Ramovi\u0107 Hamzagi\u01072<\/sup>, Nevena Milivojevi\u01071<\/sup>, Katarina Peci\u01071<\/sup>, Dragana \u0160ekli\u01071<\/sup>, Milena Jovanovi\u01073<\/sup>, Nikolina Kastratovi\u01072<\/sup>, Ana Miri\u01071<\/sup>, Tijana \u0110uki\u01071<\/sup>, Ivica Petrovi\u01072<\/sup>, Vladimir Juri\u0161i\u01072<\/sup>, Biljana Ljuji\u01072<\/sup>, Nenad Filipovi\u01074,5<\/sup><\/p>\n\n\n\n

1<\/sup>Institute for Information Technologies Kragujevac University of Kragujevac Jovana Cviji\u0107a bb 34000 Kragujevac Serbia<\/p>\n\n\n\n

2<\/sup>Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovi\u0107a 69, 34000 Kragujevac, Serbia<\/p>\n\n\n\n

3<\/sup>Faculty of Sciences, University of Kragujevac, Radoja Domanovi\u0107a 12, 34000 Kragujevac, Serbia<\/p>\n\n\n\n

4<\/sup>Faculty of Engineering, University of Kragujevac, Sestre Janji\u0107 6, 34000 Kragujevac, Serbia<\/p>\n\n\n\n

5<\/sup>Bioengineering Research and Development Center (BioIRC), Prvoslava Stojanovica 6, 34000 Kragujevac, Serbia<\/p>\n\n\n\n

msc.katarina.virijevic [at] gmail.com<\/p>\n\n\n\n

Abstract<\/strong><\/p>\n\n\n\n

In this study, colon, and breast cancer cell lines (HCT-116 and MDA-MB-231), as well as healthy lung fibroblast cell line (MRC-5) were treated with commercial chemotherapeutic agents. The obtained results showed a decrease in viability and the occurrence of predominantly late apoptosis upon treatment, as well as a strong correlation between parameters. A mathematical model was developed and used to gain a better understanding of the investigated processes. This method can accurately simulate the behavior of cancer cells and reliably predict their growth.<\/p>\n\n\n\n

Keywords:<\/strong> numerical modeling, cancer, cell viability, apoptosis, gene expression, cytostatics<\/p>\n\n\n\n

Acknowledgment<\/strong>: The authors are grateful for the support of the European Union\u2019s Horizon 2020 research and innovation programme (grant agreement No 952603 (SGABU)). This article reflects only the author’s view. The Commission is not responsible for any use that may be made of the information it contains. This research is supported by the Serbian Ministry of Education, Science, and Technological Development [451-03-9\/2021-14\/200378 (Institute for Information Technologies, University of Kragujevac)].<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Katarina Virijevi\u01071,5*<\/sup>, Marko \u017divanovi\u01071<\/sup>, Marina Gazdi\u0107 Jankovi\u01072<\/sup>, Amra Ramovi\u0107 Hamzagi\u01072<\/sup>, Nevena Milivojevi\u01071<\/sup>, Katarina Peci\u01071<\/sup>, Dragana \u0160ekli\u01071<\/sup>, Milena Jovanovi\u01073<\/sup>, Nikolina Kastratovi\u01072<\/sup>, Ana Miri\u01071<\/sup>, Tijana \u0110uki\u01071<\/sup>, Ivica Petrovi\u01072<\/sup>, Vladimir Juri\u0161i\u01072<\/sup>, Biljana Ljuji\u01072<\/sup>, Nenad Filipovi\u01074,5<\/sup><\/p>\n

1<\/sup>Institute for Information Technologies Kragujevac University of Kragujevac Jovana Cviji\u0107a bb 34000 Kragujevac Serbia<\/p>\n

2<\/sup>Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovi\u0107a 69, 34000 Kragujevac, Serbia<\/p>\n

3<\/sup>Faculty of Sciences, University of Kragujevac, Radoja Domanovi\u0107a 12, 34000 Kragujevac, Serbia<\/p>\n

4<\/sup>Faculty of Engineering, University of Kragujevac, Sestre Janji\u0107 6, 34000 Kragujevac, Serbia<\/p>\n

5<\/sup>Bioengineering Research and Development Center (BioIRC), Prvoslava Stojanovica 6, 34000 Kragujevac, Serbia<\/p>\n

Continue reading<\/span><\/i><\/a> <\/p>\n","protected":false},"author":162,"featured_media":0,"template":"","categories":[8],"tags":[],"yoast_head":"\nNumerical and Biological Modeling Approach in the Analysis of the Cancer Viability and Apoptosis - BelBi 2023<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Numerical and Biological Modeling Approach in the Analysis of the Cancer Viability and Apoptosis - BelBi 2023\" \/>\n<meta property=\"og:description\" content=\"Katarina Virijevi\u01071,5*, Marko \u017divanovi\u01071, Marina Gazdi\u0107 Jankovi\u01072, Amra Ramovi\u0107 Hamzagi\u01072, Nevena Milivojevi\u01071, Katarina Peci\u01071, Dragana \u0160ekli\u01071, Milena Jovanovi\u01073, Nikolina Kastratovi\u01072, Ana Miri\u01071, Tijana \u0110uki\u01071, Ivica Petrovi\u01072, Vladimir Juri\u0161i\u01072, Biljana Ljuji\u01072, Nenad Filipovi\u01074,51Institute for Information Technologies Kragujevac University of Kragujevac Jovana Cviji\u0107a bb 34000 Kragujevac Serbia2Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovi\u0107a 69, 34000 Kragujevac, Serbia3Faculty of Sciences, University of Kragujevac, Radoja Domanovi\u0107a 12, 34000 Kragujevac, Serbia4Faculty of Engineering, University of Kragujevac, Sestre Janji\u0107 6, 34000 Kragujevac, Serbia5Bioengineering Research and Development Center (BioIRC), Prvoslava Stojanovica 6, 34000 Kragujevac, Serbia Continue reading\" \/>\n<meta property=\"og:url\" content=\"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/numerical-and-biological-modeling-approach-in-the-analysis-of-the-cancer-viability-and-apoptosis\/\" \/>\n<meta property=\"og:site_name\" content=\"BelBi 2023\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-14T17:49:37+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/numerical-and-biological-modeling-approach-in-the-analysis-of-the-cancer-viability-and-apoptosis\/\",\"url\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/numerical-and-biological-modeling-approach-in-the-analysis-of-the-cancer-viability-and-apoptosis\/\",\"name\":\"Numerical and Biological Modeling Approach in the Analysis of the Cancer Viability and Apoptosis - 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