{"id":2841,"date":"2023-06-13T17:34:28","date_gmt":"2023-06-13T16:34:28","guid":{"rendered":"https:\/\/archive.belbi.bg.ac.rs\/2023\/?post_type=abstract&#038;p=2841"},"modified":"2023-06-14T18:37:23","modified_gmt":"2023-06-14T17:37:23","slug":"targeting-llps-in-disease-a-new-modality-in-drug-development","status":"publish","type":"abstract","link":"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/targeting-llps-in-disease-a-new-modality-in-drug-development\/","title":{"rendered":"Targeting LLPS in disease: a new modality in drug development"},"content":{"rendered":"\n<p>Peter Tompa<sup>1,2<\/sup><\/p>\n\n\n\n<p class=\"affiliation-para\"><sup>1<\/sup>VIB-VUB Center for Structural Biology, Brussels, Belgium<\/p>\n\n\n\n<p class=\"affiliation-para\"><sup>2<\/sup>Vrije Universiteit Brussel (VUB), Dept. DBIT, Brussels, Belgium<\/p>\n\n\n\n<p>peter.tompa [at] vub.be<\/p>\n\n\n\n<p><strong>Abstract<\/strong><\/p>\n\n\n\n<p class=\"abstract-para\">Biomolecular condensation is a process whereby many macromolecules (proteins and RNAs) form non-stoichiometric, functional assemblies. The dominant mechanism of such biomolecular condensation is liquid-liquid phase separation (LLPS), which leads to the formation of membraneless organelles (MLOs), such as the nucleolus and stress granules, in the cell. The proteins involved often have a high proportion of intrinsic structural disorder, which drive LLPS by transient, multivalent interactions. As MLOs play key roles in cell signaling, the misregulation of their formation and dissolution often leads to diseases termed \u201ccondensatopathies\u201d. In my presentation, I will outline the basic mechanisms leading to such disease states, focusing on cancer, viral infections and neurodegeneration. I will also discuss the different potential strategies for correcting these errors in cell signaling, and show through specific examples how drug candidates, \u201cc-mods\u201d capable of correcting MLO misregulation, can be developed.<\/p>\n\n\n\n<p class=\"abstract-para\"><strong>Keywords:<\/strong> LLPS databases, LLPS mechanism, LLPS targeting, condensatopathy, ALS\/FTD  <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Peter Tompa<sup>1,2<\/sup><\/p>\n<p class=\"affiliation-para\"><sup>1<\/sup>VIB-VUB Center for Structural Biology, Brussels, Belgium<\/p>\n<p class=\"affiliation-para\"><sup>2<\/sup>Vrije Universiteit Brussel (VUB), Dept. DBIT, Brussels, Belgium<\/p>\n<p> <a class=\"continue-reading-link\" href=\"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/targeting-llps-in-disease-a-new-modality-in-drug-development\/\"><span>Continue reading<\/span><i class=\"crycon-right-dir\"><\/i><\/a> <\/p>\n","protected":false},"author":162,"featured_media":0,"template":"","categories":[16],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Targeting LLPS in disease: a new modality in drug development - BelBi 2023<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Targeting LLPS in disease: a new modality in drug development - BelBi 2023\" \/>\n<meta property=\"og:description\" content=\"Peter Tompa1,21VIB-VUB Center for Structural Biology, Brussels, Belgium2Vrije Universiteit Brussel (VUB), Dept. DBIT, Brussels, Belgium Continue reading\" \/>\n<meta property=\"og:url\" content=\"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/targeting-llps-in-disease-a-new-modality-in-drug-development\/\" \/>\n<meta property=\"og:site_name\" content=\"BelBi 2023\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-14T17:37:23+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/targeting-llps-in-disease-a-new-modality-in-drug-development\/\",\"url\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/targeting-llps-in-disease-a-new-modality-in-drug-development\/\",\"name\":\"Targeting LLPS in disease: a new modality in drug development - BelBi 2023\",\"isPartOf\":{\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/#website\"},\"datePublished\":\"2023-06-13T16:34:28+00:00\",\"dateModified\":\"2023-06-14T17:37:23+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/targeting-llps-in-disease-a-new-modality-in-drug-development\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/targeting-llps-in-disease-a-new-modality-in-drug-development\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/targeting-llps-in-disease-a-new-modality-in-drug-development\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Targeting LLPS in disease: a new modality in drug development\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/#website\",\"url\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/\",\"name\":\"BelBi 2023\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/#organization\",\"name\":\"Belgrade Bioinformatics Conference\",\"url\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/wp-content\/uploads\/2023\/02\/145_97_171.png\",\"contentUrl\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/wp-content\/uploads\/2023\/02\/145_97_171.png\",\"width\":278,\"height\":500,\"caption\":\"Belgrade Bioinformatics Conference\"},\"image\":{\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Targeting LLPS in disease: a new modality in drug development - BelBi 2023","robots":{"index":"noindex","follow":"follow"},"og_locale":"en_US","og_type":"article","og_title":"Targeting LLPS in disease: a new modality in drug development - BelBi 2023","og_description":"Peter Tompa1,21VIB-VUB Center for Structural Biology, Brussels, Belgium2Vrije Universiteit Brussel (VUB), Dept. 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