{"id":2839,"date":"2023-06-13T17:34:28","date_gmt":"2023-06-13T16:34:28","guid":{"rendered":"https:\/\/archive.belbi.bg.ac.rs\/2023\/?post_type=abstract&#038;p=2839"},"modified":"2023-06-14T18:37:23","modified_gmt":"2023-06-14T17:37:23","slug":"a-tale-of-two-stories-data-driven-precision-medicine-and-precision-public-health","status":"publish","type":"abstract","link":"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/a-tale-of-two-stories-data-driven-precision-medicine-and-precision-public-health\/","title":{"rendered":"A tale of two stories: data-driven precision medicine and precision public health"},"content":{"rendered":"\n<p>Kristel Van Steen<sup>1,2<\/sup><\/p>\n\n\n\n<p class=\"affiliation-para\"><sup>1<\/sup>BIO3 Systems Genetics, GIGA-R, Universit\u00e9 de Li\u00e8ge, 4000 Li\u00e8ge, Belgium<\/p>\n\n\n\n<p class=\"affiliation-para\"><sup>2<\/sup>BIO3 Systems Medicine, Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium<\/p>\n\n\n\n<p>kristel.vansteen [at] uliege.be<\/p>\n\n\n\n<p><strong>Abstract<\/strong><\/p>\n\n\n\n<p class=\"abstract-para\">Big Data offers opportunities in health care to refine individuals&#8217; characterization and thus complement traditional precision medicine approaches toward individual-targeted prevention, diagnosis and treatment management. Not surprisingly, network theory plays a vital role in modelling Big Data: the higher the number of measurements, the higher the number of potential relationships or dependencies among them. Recent developments have shown the complementary value of personalizing population-based networks for individuals (Menche et al. 2017, Dimitrakopoulos et al. 2018) or deriving individual-specific networks via populations of cells (Gosak et al. 2018, Li et al. 2023). <\/p>\n\n\n\n<p class=\"abstract-para\">Individual-specific networks do not necessarily require repeated measurements over time or in space. Reverse-engineered individual-specific networks (Kuijjer et al. 2019) from an aggregate network (hereafter referred to as ISNs) allow for investigating the impact of individual-level network wirings, paths or connectivity on medical decision-making in the individual&#8217;s interest. Wondering about the utility of these ISNs, we illustrate by example from microbiome and gene co-expression experiments how ISNs give complementary insights in dynamic network biomarker identification and can reveal (genetic modifiers of) co-eQTLs as direct or indirect regulators of gene co-expression.<\/p>\n\n\n\n<p class=\"abstract-para\"><strong>Keywords:<\/strong> individual-specific networks, precision medicine, precision public health, Big Data science <\/p>\n\n\n\n<p class=\"abstract-para\"><strong>Acknowledgement:<\/strong> This work received funding from the European Union&#8217;s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreements N\u00b0 813533 (<a href=\"https:\/\/mlfpm.eu\/\">mlfpm.eu<\/a>) and N\u00b0 860895 (<a href=\"https:\/\/h2020transys.eu\/\">h2020transys.eu<\/a>). We are grateful to all former and current BIO3 members for inspiring discussions. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kristel Van Steen<sup>1,2<\/sup><\/p>\n<p class=\"affiliation-para\"><sup>1<\/sup>BIO3 Systems Genetics, GIGA-R, Universit\u00e9 de Li\u00e8ge, 4000 Li\u00e8ge, Belgium<\/p>\n<p class=\"affiliation-para\"><sup>2<\/sup>BIO3 Systems Medicine, Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium<\/p>\n<p> <a class=\"continue-reading-link\" href=\"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/a-tale-of-two-stories-data-driven-precision-medicine-and-precision-public-health\/\"><span>Continue reading<\/span><i class=\"crycon-right-dir\"><\/i><\/a> <\/p>\n","protected":false},"author":162,"featured_media":0,"template":"","categories":[16],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A tale of two stories: data-driven precision medicine and precision public health - 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