{"id":2834,"date":"2023-06-13T09:41:47","date_gmt":"2023-06-13T08:41:47","guid":{"rendered":"https:\/\/archive.belbi.bg.ac.rs\/2023\/?post_type=abstract&#038;p=2834"},"modified":"2023-06-14T18:37:23","modified_gmt":"2023-06-14T17:37:23","slug":"the-complete-solution-and-interpretation-algorithms-for-large-field-of-view-and-high-resolution-spatial-transcriptomics","status":"publish","type":"abstract","link":"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/the-complete-solution-and-interpretation-algorithms-for-large-field-of-view-and-high-resolution-spatial-transcriptomics\/","title":{"rendered":"The complete solution and interpretation algorithms for large field-of-view and high-resolution spatial transcriptomics"},"content":{"rendered":"\n<p>Shuangsang Fang<sup>1<\/sup><\/p>\n\n\n\n<p class=\"affiliation-para\"><sup>1<\/sup>BGI-Research, Belgrade, Serbia<\/p>\n\n\n\n<p><strong>Abstract<\/strong><\/p>\n\n\n\n<p class=\"abstract-para\">The large field-of-view and high-resolution spatial transcriptomics technology can reveal and answer scientific questions that cannot be discovered or elucidated by low-resolution spatial transcriptomics. Obtaining expression profiles at the single-cell level from high-resolution spatial transcriptomics requires sophisticated data processing and interpretation strategies, including extensive image data processing, transcriptome data processing, integration analysis. At the same time, the introduction of spatial information helps with the annotation of single cells at the tissue level and the study of tissue structure and function, while cell clustering and cell annotation are important foundations for subsequent in-depth analysis. Cell annotation can be divided into clustering and re-annotation based on marker genes and end-to-end cell annotation based on reference datasets. The choice between the two depends on whether markers are easier to obtain or whether reference datasets with consistent data backgrounds are easier to obtain. The algorithm team at BGI Research Institute has conducted extensive algorithm research and development on data interpretation strategies, cell clustering algorithms, and cell annotation algorithms for large field-of-view and high-resolution spatial transcriptomics technology, with the aim of providing comprehensive, efficient, and highly reliable data analysis algorithms, tools and platform support.<\/p>\n\n\n","protected":false},"excerpt":{"rendered":"<p>Shuangsang Fang<sup>1<\/sup><\/p>\n<p class=\"affiliation-para\"><sup>1<\/sup>BGI-Research, Belgrade, Serbia<\/p>\n<p> <a class=\"continue-reading-link\" href=\"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/the-complete-solution-and-interpretation-algorithms-for-large-field-of-view-and-high-resolution-spatial-transcriptomics\/\"><span>Continue reading<\/span><i class=\"crycon-right-dir\"><\/i><\/a> <\/p>\n","protected":false},"author":162,"featured_media":0,"template":"","categories":[17],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The complete solution and interpretation algorithms for large field-of-view and high-resolution spatial transcriptomics - BelBi 2023<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The complete solution and interpretation algorithms for large field-of-view and high-resolution spatial transcriptomics - BelBi 2023\" \/>\n<meta property=\"og:description\" content=\"Shuangsang Fang11BGI-Research, Belgrade, Serbia Continue reading\" \/>\n<meta property=\"og:url\" content=\"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/the-complete-solution-and-interpretation-algorithms-for-large-field-of-view-and-high-resolution-spatial-transcriptomics\/\" \/>\n<meta property=\"og:site_name\" content=\"BelBi 2023\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-14T17:37:23+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/the-complete-solution-and-interpretation-algorithms-for-large-field-of-view-and-high-resolution-spatial-transcriptomics\/\",\"url\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/the-complete-solution-and-interpretation-algorithms-for-large-field-of-view-and-high-resolution-spatial-transcriptomics\/\",\"name\":\"The complete solution and interpretation algorithms for large field-of-view and high-resolution spatial transcriptomics - BelBi 2023\",\"isPartOf\":{\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/#website\"},\"datePublished\":\"2023-06-13T08:41:47+00:00\",\"dateModified\":\"2023-06-14T17:37:23+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/the-complete-solution-and-interpretation-algorithms-for-large-field-of-view-and-high-resolution-spatial-transcriptomics\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/the-complete-solution-and-interpretation-algorithms-for-large-field-of-view-and-high-resolution-spatial-transcriptomics\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/the-complete-solution-and-interpretation-algorithms-for-large-field-of-view-and-high-resolution-spatial-transcriptomics\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The complete solution and interpretation algorithms for large field-of-view and high-resolution spatial transcriptomics\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/#website\",\"url\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/\",\"name\":\"BelBi 2023\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/#organization\",\"name\":\"Belgrade Bioinformatics Conference\",\"url\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/wp-content\/uploads\/2023\/02\/145_97_171.png\",\"contentUrl\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/wp-content\/uploads\/2023\/02\/145_97_171.png\",\"width\":278,\"height\":500,\"caption\":\"Belgrade Bioinformatics Conference\"},\"image\":{\"@id\":\"https:\/\/archive.belbi.bg.ac.rs\/2023\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The complete solution and interpretation algorithms for large field-of-view and high-resolution spatial transcriptomics - BelBi 2023","robots":{"index":"noindex","follow":"follow"},"og_locale":"en_US","og_type":"article","og_title":"The complete solution and interpretation algorithms for large field-of-view and high-resolution spatial transcriptomics - BelBi 2023","og_description":"Shuangsang Fang11BGI-Research, Belgrade, Serbia Continue reading","og_url":"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/the-complete-solution-and-interpretation-algorithms-for-large-field-of-view-and-high-resolution-spatial-transcriptomics\/","og_site_name":"BelBi 2023","article_modified_time":"2023-06-14T17:37:23+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/the-complete-solution-and-interpretation-algorithms-for-large-field-of-view-and-high-resolution-spatial-transcriptomics\/","url":"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/the-complete-solution-and-interpretation-algorithms-for-large-field-of-view-and-high-resolution-spatial-transcriptomics\/","name":"The complete solution and interpretation algorithms for large field-of-view and high-resolution spatial transcriptomics - BelBi 2023","isPartOf":{"@id":"https:\/\/archive.belbi.bg.ac.rs\/2023\/#website"},"datePublished":"2023-06-13T08:41:47+00:00","dateModified":"2023-06-14T17:37:23+00:00","breadcrumb":{"@id":"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/the-complete-solution-and-interpretation-algorithms-for-large-field-of-view-and-high-resolution-spatial-transcriptomics\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/the-complete-solution-and-interpretation-algorithms-for-large-field-of-view-and-high-resolution-spatial-transcriptomics\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/archive.belbi.bg.ac.rs\/2023\/abstract\/the-complete-solution-and-interpretation-algorithms-for-large-field-of-view-and-high-resolution-spatial-transcriptomics\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/archive.belbi.bg.ac.rs\/2023\/"},{"@type":"ListItem","position":2,"name":"The complete solution and interpretation algorithms for large field-of-view and high-resolution spatial transcriptomics"}]},{"@type":"WebSite","@id":"https:\/\/archive.belbi.bg.ac.rs\/2023\/#website","url":"https:\/\/archive.belbi.bg.ac.rs\/2023\/","name":"BelBi 2023","description":"","publisher":{"@id":"https:\/\/archive.belbi.bg.ac.rs\/2023\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/archive.belbi.bg.ac.rs\/2023\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/archive.belbi.bg.ac.rs\/2023\/#organization","name":"Belgrade Bioinformatics Conference","url":"https:\/\/archive.belbi.bg.ac.rs\/2023\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/archive.belbi.bg.ac.rs\/2023\/#\/schema\/logo\/image\/","url":"https:\/\/archive.belbi.bg.ac.rs\/2023\/wp-content\/uploads\/2023\/02\/145_97_171.png","contentUrl":"https:\/\/archive.belbi.bg.ac.rs\/2023\/wp-content\/uploads\/2023\/02\/145_97_171.png","width":278,"height":500,"caption":"Belgrade Bioinformatics Conference"},"image":{"@id":"https:\/\/archive.belbi.bg.ac.rs\/2023\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/archive.belbi.bg.ac.rs\/2023\/wp-json\/wp\/v2\/abstract\/2834"}],"collection":[{"href":"https:\/\/archive.belbi.bg.ac.rs\/2023\/wp-json\/wp\/v2\/abstract"}],"about":[{"href":"https:\/\/archive.belbi.bg.ac.rs\/2023\/wp-json\/wp\/v2\/types\/abstract"}],"author":[{"embeddable":true,"href":"https:\/\/archive.belbi.bg.ac.rs\/2023\/wp-json\/wp\/v2\/users\/162"}],"wp:attachment":[{"href":"https:\/\/archive.belbi.bg.ac.rs\/2023\/wp-json\/wp\/v2\/media?parent=2834"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/archive.belbi.bg.ac.rs\/2023\/wp-json\/wp\/v2\/categories?post=2834"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/archive.belbi.bg.ac.rs\/2023\/wp-json\/wp\/v2\/tags?post=2834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}