Katarina Virijević1,5*, Marko Živanović1, Marina Gazdić Janković2, Amra Ramović Hamzagić2, Nevena Milivojević1, Katarina Pecić1, Dragana Šeklić1, Milena Jovanović3, Nikolina Kastratović2, Ana Mirić1, Tijana Đukić1, Ivica Petrović2, Vladimir Jurišić2, Biljana Ljujić2, Nenad Filipović4,5
1Institute for Information Technologies Kragujevac University of Kragujevac Jovana Cvijića bb 34000 Kragujevac Serbia
2Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića 69, 34000 Kragujevac, Serbia
3Faculty of Sciences, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia
4Faculty of Engineering, University of Kragujevac, Sestre Janjić 6, 34000 Kragujevac, Serbia
5Bioengineering Research and Development Center (BioIRC), Prvoslava Stojanovica 6, 34000 Kragujevac, Serbia
msc.katarina.virijevic [at] gmail.com
Abstract
In this study, colon, and breast cancer cell lines (HCT-116 and MDA-MB-231), as well as healthy lung fibroblast cell line (MRC-5) were treated with commercial chemotherapeutic agents. The obtained results showed a decrease in viability and the occurrence of predominantly late apoptosis upon treatment, as well as a strong correlation between parameters. A mathematical model was developed and used to gain a better understanding of the investigated processes. This method can accurately simulate the behavior of cancer cells and reliably predict their growth.
Keywords: numerical modeling, cancer, cell viability, apoptosis, gene expression, cytostatics
Acknowledgment: The authors are grateful for the support of the European Union’s Horizon 2020 research and innovation programme (grant agreement No 952603 (SGABU)). This article reflects only the author’s view. The Commission is not responsible for any use that may be made of the information it contains. This research is supported by the Serbian Ministry of Education, Science, and Technological Development [451-03-9/2021-14/200378 (Institute for Information Technologies, University of Kragujevac)].
