Jose M. G. Vilar1,2
1Biofisika Institute (CSIC, UPV/EHU), University of the Basque Country (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain
2IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain
j.vilar [at] ikerbasque.org
Abstract
Inferring the timing and amplitude of perturbations in epidemiological systems from their stochastically spread low-resolution outcomes is as relevant as challenging. It is a requirement for current approaches to overcome the need to know the details of the perturbations to proceed with the analyses. However, the general problem of connecting epidemiological curves with the underlying incidence lacks the highly effective methodology present in other inverse problems, such as super-resolution and dehazing from machine vision. I will present an unsupervised physics-informed convolutional neural network approach in reverse to connect death records with an incidence that allows the identification of regime changes at a single-day resolution. Applied to COVID-19 data with proper regularization and model-selection criteria, the approach can identify the implementation and removal of lockdowns and other nonpharmaceutical interventions with ± 0.9-day accuracy over the span of a year.
Keywords: bioinformatics, physics-informed neural networks, epidemiology
Acknowledgement: J.M.G.V. acknowledges support from Ministerio de Ciencia e Innovacion under grants PGC2018-101282-B-I00 and PID2021-128850NB-I00 (MCI/AEI/FEDER, UE).
